My face.

Christopher Jennison


Professor Christopher Jennison

Department: Department of Mathematical Sciences
Job Title: Professor of Statistics

Telephone: +44 1225 385674

E-mail Address: C.Jennison@bath.ac.uk

Postal Address:


Book

Group Sequential Methods with Applications to Clinical Trials by Christopher Jennison and Bruce W. Turnbull.

Publications

Full list of publications: pdf file

Diabetes Research

I am an invesitgator in the DIRECT research project, funded by the EU Innovative Medicines Initiative and the MASTERMIND research project, funded by the Medical Research Council.

Short courses

List of half-day, one-day and two-day short courses on Group Sequential and Adaptive Clinical Trials

Consultancy

I offer consultancy on the design and analysis of clinical trials.

Recent talks

Talk at Sanofi, Chilly-Mazarin, Paris, July 2014 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design" pdf file

Talk at Sanofi, Chilly-Mazarin, Paris, July 2014 "Designing an Adaptive Trial using a Combination Test for a Survival Endpoint" pdf file

Introduction to discussion session on "Personalized Medicine and Subgroup Selection" led by Chris Jennison and Robert A. Beckman at Symposium on Small Populations, Vienna, July 2014 ppt file

Talk at European Clinical Research Infrastructure Network, International Clinical Trials' Day, Luxembourg, May 2014 "When are Adaptive Designs really Needed" pdf file

Talk by C. Jennison, M. Jenkins and A. Stone at Smart Trials 2014, London, April 2014 "Designing an Adaptive Trial using a Combination Test for a Survival Endpoint" pdf file

Talk by C. Jennison, M. Jenkins and A. Stone at SMi Conference on Adaptive Designs in Clinical Trials, London, March 2014 "Designing an Adaptive Trial using a Combination Test for a Survival Endpoint" pdf file

Tutorial by C. Jennison and B. W. Turnbull at 69th Deming Conference on Applied Statistics, Atlantic City, December 2013 "Monitoring clinical trial outcomes with delayed response: Incorporating ``pipeline'' data in group sequential and adaptive designs''. pdf file.

Seminar at University of North Carolina, December 2013 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping" pdf file. See also the companion paper "Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping" by C. Jennison and B.W. Turnbull, pdf file

Talk at 8th International Conference on Multiple Comparison Procedures, Southampton, July 2013 "Group Sequential Designs: Theory, Computation and Optimisation" pdf file. See also the companion paper "Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping" by C. Jennison and B.W. Turnbull, pdf file

Talk by C. Jennison, M. Jenkins and A. Stone at ICSA-ISBS Joint Conference, Bethesda MD, June 2013 "Designing an Adaptive Trial using a Combination Test for a Survival Endpoint" pdf file

Talk by C. Jennison, M. Jenkins and A. Stone at Cytel EAST User Group Meeting, Basel, May 2013 "Designing an Adaptive Trial using a Combination Test for a Survival Endpoint" pdf file To see a video of this presentation click here

Seminar at University of York, May 2013 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping" pdf file. See also the companion paper "Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping" by C. Jennison and B.W. Turnbull, pdf file

Seminar at Roche, Welwyn Garden City, May 2013 "Adaptive Sample Size Modification in Clinical Trials: Start Small then Ask for More?" pdf file

Talk by C. Jennison and B. W. Turnbull at SMi conference: Adaptive Designs in Clinical Trials, London, April 2013 "Adaptive Sample Size Modification in Clinical Trials: Start Small then Ask for More?" pdf file, ppt file

Talk at Workshop on Special Topics on Sequential Methodology, University Medical Centre Utrecht, March 2013 "Group Sequential Tests for Delayed Responses" pdf file

Seminar at Cambridge University, November 2012 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping" pdf file. See also the companion paper "Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping" by C. Jennison and B.W. Turnbull, pdf file

Seminar at Lancaster University, October 2012 "Adaptive sample size modification in clinical trials: Start small then ask for more?" pdf file

Slides for PSI Workshop: Latimer House, October 2012 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file

Talk by C. Jennison and L. V. Hampson at BfArM/DIA Statistics Workshop, Bonn, October 2012 "Group Sequential Tests for Delayed Responses". pdf file, ppt file

Talk at GSK, BAC Conference, Ware, October 2012 "Effective design of Phase II and Phase III trials: an over-arching approach". pdf file

Talk at Recent Advances in Adaptive Designs organised by PSI and Aptiv Solutions, London, July 2012 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design". pdf file

Paper by L. V. Hampson and C. Jennison read to the Royal Statistical Society, at a meeting organised by the Research Section, 16 May 2012 "Group Sequential Tests for Delayed Responses". pdf file

Talk at PSI conference: The Belfry, May 2012 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file

Talk at SMi conference: Adaptive Designs in Clinical Drug Development, London, March 2012 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file

Seminar at Chalmers University, Gothenburg, January 2012 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file

Talk at AstraZeneca, Molndal, Sweden, January 2012 "The roles of short term endpoints in clinical trial planning and design" pdf file

Seminar at GSK, Stevenage, December 2011 "Adaptive sample size modification in clinical trials: Start small then ask for more?" pdf file

Seminar at Roche, Welwyn Garden City, December 2011 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file

Seminar at University of Bath, December 2011 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file

Tutorial at Biopharmaceutical Applied Statistics Symposium (BASS) XVIII, Savannah, Georgia, November 2011 "Adaptive sample size modification in clinical trials: Start small then ask for more?" pdf file

Talk at Workshop on the Design and Analysis of Clinical Trials, Institute for Mathematical Sciences, National University of Singapore, October 2011 "Group sequential and adaptive clinical trials". pdf file

Talk at 2nd Conference of the Central European Network --- CEN 2011, Zurich, September 2011 "Adaptive population enrichment: switching to a sub-population in response to interim trial data". pdf file

Talk at ADAPT conference on Adaptive Clinical Trials, Philadelphia, September 2011 "Effective design of Phase II and Phase III trials: an over-arching approach". pdf file

Talk at workshop on Design of Experiments in Healthcare, Isaac Newton Institute, Cambridge, August 2011 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file

Talk at 3rd International Workshop in Sequential Methodologies, Stanford, June 2011 "Jointly optimal design of Phase II and Phase III clinical trials: an over-arching approach". pdf file

Talk at Royal Netherlands Academy of Arts and Sciences colloquium "Cost Efficient and Optimal Designs for Social and Biomedical Sciences", Amsterdam, April 2011 "Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping". pdf file. See also the companion paper "Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping" by C. Jennison and B.W. Turnbull, pdf file

Talk at Challenges in Statistics and Operations Research Conference: Kuwait, March 2011 "Decision theory, dynamic programming and optimal stopping of clinical trials". pdf file. See also the companion paper "Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping" by C. Jennison and B.W. Turnbull, pdf file

Talk at 2nd International Symposium on Biopharmaceutical Statistics: Berlin, March 2011 "Optimising the PhaseIIb, Phase III process". pdf file

Seminar at Durham University, February 2011 "Data combination in seamless Phase II/III designs". pdf file

Talk at SMi conference: Adaptive Designs in Clinical Drug Development, London, February 2011 "Statistical inference after group sequential and adaptive clinical trials". pdf file

Interview recorded at Pharma-IQ conference in London, December 2010 "Adaptive Design in Clinical Trials: Past, Present and Future" click here

Seminar at University of Leeds, November 2010 "Data combination in seamless Phase II/III designs". pdf file

Seminar at Medical University of South Carolina, Charleston, SC, October 2010 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design". pdf file

Seminar at Chalmers University, Gothenburg, August 2010 "Data combination in seamless Phase II/III designs". pdf file

Talk at AstraZeneca, Molndal, Sweden, August 2010 "Group Sequential and Adaptive Designs: Where are we now?" pdf file

Talk at IMS 73rd Annual Meeting, Gothenburg, Sweden, August 2010 "Decision theory, dynamic programming and optimal stopping of clinical trials". pdf file

Seminar at Merck Serono, Geneva, Switzerland, June 2010 "Group Sequential and Adaptive Designs: Where are we now?" pdf file

Seminar at Children's Oncology Group, Los Angeles, February 2010 "Group Sequential and Adaptive Designs: Where are we now?" (with additional material on short term/surrogate endpoints) pdf file

Seminar at City of Hope, Duarte, California, February 2010 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design". pdf file

Seminar at City of Hope, Duarte, California, February 2010 "Group Sequential and Adaptive Designs: Where are we now?" pdf file

Talk at VIB Adaptive Trials 2009 Conference, Brussels, December 2009 "The Roles of Short Term Endpoints in Clinical Trial Planning and Design". pdf file

Seminar at University of Kent, December 2009 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping". pdf file

Talk at 6th International Meeting on Statistical Methods in Biopharmacy, Paris, September 2009 "Group Sequential and Adaptive Designs: Where are we now?" pdf file

ACRP Webinar, September 2009 "Adaptive Clinical Trials: What do they Offer?" pdf file

Contribution to panel discussion, Joint Statistical Meetings, Washington DC, August 2009 "Adaptive Design: Where Are We Now?" pdf file

Talk at 2009 Quality & Productivity Research Conference, IBM T. J. Watson Research Center, Yorktown Heights, New York, June 2009 "Data Combination in Seamless Phase II/III Designs". pdf file

Talk at 6th International Conference on Multiple Comparison Procedures, Tokyo, March 2009 "Data Combination in Seamless Phase II/III Designs". pdf file

Talk at Pfizer, Sandwich, UK, February 2009 "Critical Appraisal of Adaptive Methods". pdf file

Talk at SMi conference: Adaptive Designs in Clinical Drug Development, London, February 2009 "Critical Appraisal of Adaptive Methods". pdf file

Seminar at University of Bath, December 2008 "Interim Monitoring of Clinical Trials: Decision Theory, Dynamic Programming and Optimal Stopping". pdf file

Talk at European Leukaemia Network Workshop, Munich, October 2008 "Adaptive sample size re-estimation". pdf file

Talk in KOL lecture series: September 2008 "Comparing Adaptive Designs and the Classical Group Sequential Approach to Clinical Trial Design". pdf file

Talk at VIB conference: Adaptive Trials 2008, Barcelona, September 2008 "Critical Appraisal of Adaptive Methods". pdf file

Talk at Joint Statistical Meetings, Denver, August 2008 "Adaptive designs: Why, how and when?". pdf file

Talk at ISBS Conference, Shanghai, July 2008 "Adaptive designs: Why, how and when?". pdf file

Talk at Informa Conference, Adaptive Designs for Clinical Development, London, May 2008 "Comparing adaptive designs and the classical, sequential approach". pdf file

Talk at ENAR Biometrics Conference, Arlington, March 2008 "Adaptive designs: Why, how and when?". pdf file

Talks prior to 2008

Recent papers

"Group sequential tests for delayed responses" by Lisa Hampson and Christopher Jennison. pdf file. This paper was read and discussed at a meeting of the Research Section of the Royal Statistical Society on 16 May, 2012, see J. Royal Statistical Society, B, 2012, 3-54, doi: 10.1111/j.1467-9868.2012.01030.x

"Interim monitoring of clinical trials: Decision theory, dynamic programming and optimal stopping" by Christopher Jennison and Bruce W. Turnbull. pdf file (a version of this paper will appear in Kuwait Journal of Science, 2013 .)

"An adaptive seamless design with subpopulation selection" by Martin Jenkins, Andrew Stone and Christopher Jennison. word file (a revised version of this paper is in Pharmaceutical Statistics, 2011, 347-356, doi: 10.1002/pst.472).

"Mapping electron density in the ionosphere: a principal component MCMC algorithm" by Eman Khorsheed, Merrilee Hurn and Christopher Jennison. pdf file (a revised version of this paper is in Computational Statistics and Data Analysis, 2011, 338-352; doi:10.1016/j.csda.2010.04.029).

"Three dimensional statistical image analysis and confocal microscopy" by Fahimah Al-Awadhi, Merrilee Hurn and Christopher Jennison. pdf file (a revised version of this paper is in Journal of Applied Statistics, 2011, 29-46; doi: 10.1080/02664760903117747).

"From group sequential to adaptive designs" by Christopher Jennison and Bruce W. Turnbull. pdf file (a revised version of this paper is in Handbook of Adaptive Design in Pharmaceutical and Clinical Development, eds. A. Pong and S.-C. Chow, New York: CRC Press, 5-1 - 5-25, 2011).

"Optimal group sequential designs for simultaneous testing of superiority and non-inferiority" by Fredrik Ohrn and Christopher Jennison. pdf file (a revised version of this paper is in Statistics in Medicine, 2010, 743-759; doi: 10.1002/sim.3790).

"Comparing efficiency for adaptive and non-adaptive group sequential designs" by Bruce W. Turnbull and Christopher Jennison. pdf file (a revised version of this paper is in Proceedings of the 57th ISI conference, Durban, South Africa, August 2009 .

"Adaptive seamless designs: Selection and prospective testing of hypotheses" by Christopher Jennison and Bruce W. Turnbull. pdf file (a revised version of this paper is in J. Biopharmaceutical Statistics, 2007, 1135-1161; doi: 10.1080/10543400701645215).

"Adaptive and non-adaptive group sequential tests" by Christopher Jennison and Bruce W. Turnbull. This paper derives theory of optimal adaptive and non-adaptive group sequential designs, extending the theoretical results of Tsiatis and Mehta (Biometrika, 2003) and explaining the implications of this theory. It also gives numerical results showing the relative efficiency of the best possible adaptive and non-adaptive designs: pdf file (a revised version of this paper is in Biometrika, 2006, 1-21; doi: 10.1093/biomet/93.1.1).

"Efficient group sequential designs when there are several effect sizes under consideration" by Christopher Jennison and Bruce W. Turnbull. pdf file (a revised version of this paper is in Statistics in Medicine, 2006, 917-932; doi: 10.1002/sim.2251). Technical report with additional tables: pdf file

"Meta-analyses and adaptive group sequential designs in the clinical development process" by Christopher Jennison and Bruce W. Turnbull. pdf file (a revised version of this paper is in J. Biopharmaceutical Statistics, 2005, 537-558; doi: 10.1081/bip-200062273).

"Improving the acceptance rate of reversibe jump MCMC proposals" by Fahimah Al-Awadhi, Merrilee Hurn and Christopher Jennison. pdf file (a revised version of this paper is in Statistics and Probability Letters, 2004, Vol 69, 189-198; doi: 10.1002/sim.1457)

"Statistical image analysis for a confocal microscopy 2D section of cartilage growth" by Fahimah Al-Awadhi, Merrilee Hurn and Christopher Jennison. pdf file (a revised version of this paper is in Applied Statistics, 2004, 31-49; doi: 0035.9254/04/53031)

"Mid-course sample size modification in clinical trials based on the observed treatment effect" by Christopher Jennison and Bruce W. Turnbull presented at 4th International Meeting on Statistical Methods in Biopharmacy, Paris, September 2001: pdf file (a revised version of this paper is in Statistics in Medicine, 2003, 971-993; doi: 10.1002/sim.1457).

A not so recent paper and Technical Report

"Asymptotically optimal procedures for sequential adaptive selection of the best of several normal means" by Christopher Jennison, Iain M. Johnstone and Bruce W. Turnbull, In Statistical Decision Theory and Related Topics III, Vol. 2, (eds S. S. Gupta and J. Berger) New York: Academic Press 2, 55-86. pdf file

"Asymptotically optimal procedures for sequential adaptive selection of the best of several normal means" by Christopher Jennison, Iain M. Johnstone and Bruce W. Turnbull, School of OR and IE, Cornell University, Technical Report 463, June 1980. pdf file


Associate Editor of

Chair (2014-2015) of

Committee member of the Bradford on Avon Film Society.


Bradford on Avon Thai Festival and cookery competition photos (all) or (selected).

Sentosa photos.


[University of Bath]